Recent Publications

Within the past three years. For the full list of publications please consult PubMed.


Orai3 and Orai1 mediate CRAC channel function and metabolic reprogramming in B cells
Scott M Emrich, Ryan E Yoast, Xuexin Zhang, Adam J Fike, Yin-Hu Wang, Kristen N Bricker, Anthony Y Tao, Ping Xin, Vonn Walter, Martin T Johnson, Trayambak Pathak, Adam C Straub, Stefan Feske, Ziaur SM Rahman, Trebak M.
eLife2023 Feb 21;12:e84708.


The airway smooth muscle sodium/calcium exchanger NCLX is critical for airway remodeling and hyperresponsiveness in asthma.
Johnson MT, Benson JC, Pathak T, Xin P, McKernan AS, Emrich SM, Yoast RE, Walter V, Straub AC, Trebak M.
J Biol Chem. 2022 Jul 13;102259.

Curcumin and NCLX inhibitors share anti-tumoral mechanisms in microsatellite-instability-driven colorectal cancer.
Guéguinou M, Ibrahim S, Bourgeais J, Robert A, Pathak T, Zhang X, Crottès D, Dupuy J, Ternant D, Monbet V, Guibon R, Flores-Romero H, Lefèvre A, Lerondel S, Le Pape A, Dumas JF, Frank PG, Girault A, Chautard R, Guéraud F, García-Sáez AJ, Ouaissi M, Emond P, Sire O, Hérault O, Fromont-Hankard G, Vandier C, Tougeron D, Trebak M, Raoul W, Lecomte T.
Cell Mol Life Sci. 2022 May 8;79(6):284

Orai3 and Orai1 are essential for CRAC channel function and metabolic reprogramming in B cells
Emrich S, Yoast R, Zhang X, Fike A, Wang YH, Bricker K, Tao A, Xin P, Walter V, Johnson MT, Pathak T, Straub AC, Feske S, Rahman Z, Trebak M.
Available at BioRXiv. 2022 May.

Mitochondrial Calcium Uniporter Drives Metastasis and Confers a Targetable Cystine Dependency in Pancreatic Cancer.
Wang X, Li Y, Li Z, Lin S, Wang H, Sun J, Lan C, Wu L, Sun D, Huang C, Singh PK, Hempel N, Trebak M, DeNicola GM, Hao J, Yang S.
Cancer Res. 2022 Jun 15;82(12):2254-2268.

STIM1-dependent peripheral coupling governs the contractility of vascular smooth muscle cells.
Krishnan V, Ali S, Gonzales AL, Thakore P, Griffin CS, Yamasaki E, Alvarado MG, Johnson MT, Trebak M, Earley S.
Elife. 2022 Feb 11;11:e70278.

Functional communication between IP3R and STIM2 at subthreshold stimuli is a critical checkpoint for initiation of SOCE.
Ahmad M, Ong HL, Saadi H, Son GY, Shokatian Z, Terry LE, Trebak M, Yule DI, Ambudkar I.
Proc Natl Acad Sci U S A. 2022 Jan 18;119(3):e2114928118.

STIM1 is a core trigger of airway smooth muscle remodeling and hyperresponsiveness in asthma.
Johnson MT, Xin P, Benson JC, Pathak T, Walter V, Emrich SM, Yoast RE, Zhang X, Cao G, Panettieri RA Jr, Trebak M.
Proc Natl Acad Sci U S A. 2022 Jan 4;119(1):e2114557118.

Physiological Functions of CRAC Channels.
Emrich SM, Yoast RE, Trebak M.
Annu Rev Physiol. 2022 Feb 10;84:355-379. doi: 10.1146/annurev-physiol-052521-013426. Epub 2021 Oct 12.


PKC-ε regulates vesicle delivery and focal exocytosis for efficient IgG-mediated phagocytosis.
D’Amico AE, Wong AC, Zajd CM, Zhang X, Murali A, Trebak M, Lennartz MR.
J Cell Sci. 2021 Nov 1;134(21):jcs258886.

The Mitochondrial Ca2+ uniporter is a central regulator of interorganellar Ca2+ transfer and NFAT activation.
Yoast RE, Emrich SM, Zhang X, Xin P, Arige V, Pathak T, Benson JC, Johnson MT, Abdelnaby AE, Lakomski N, Hempel N, Han JM, Dupont G, Yule DI, Sneyd J, Trebak M.
J Biol Chem. 2021 Oct;297(4):101174.

A protocol for detecting elemental calcium signals (Ca2+ puffs) in mammalian cells using total internal reflection fluorescence microscopy.
Arige V, Emrich SM, Yoast RE, Trebak M, Yule DI.
STAR Protoc. 2021 Jun 17;2(3):100618.

Orai channel C-terminal peptides are key modulators of STIM-Orai coupling and calcium signal generation.
Baraniak JH Jr, Zhou Y, Nwokonko RM, Jennette MR, Kazzaz SA, Stenson JM, Whitsell AL, Wang Y, Trebak M, Gill DL.
Cell Rep. 2021 Jun 29;35(13):109322.

Antipsychotic drugs elicit cytotoxicity in glioblastoma multiforme in a calcium-dependent, non-D2 receptor-dependent, manner.
Weissenrieder JS, Reed JL, Moldovan GL, Johnson MT, Trebak M, Neighbors JD, Mailman RB, Hohl RJ.
Pharmacol Res Perspect. 2021 May;9(3):e00689.

Rheumatoid arthritis: Relief of IKAROS transcriptional repression of Orai3 in T-cells.
Emrich SM, Yoast RE, Trebak M.
Cell Calcium. 2021 Apr 10;97:102409. 

Cardiac-Specific Deletion of Orai3 Leads to Severe Dilated Cardiomyopathy and Heart Failure in Mice.
Gammons J, Trebak M, Mancarella S.
J Am Heart Assoc. 2021 Apr 20;10(8):e019486.

Omnitemporal choreographies of all five STIM/Orai and IP3Rs underlie the complexity of mammalian Ca2+ signaling.
Emrich SM, Yoast RE, Xin P, Arige V, Wagner LE, Hempel N, Gill DL, Sneyd J, Yule DI, Trebak M.
Cell Rep. 2021 Mar 2;34(9):108760.

[NCLX exchanger: An ambivalent role in colorectal cancer timeline].
Guéguinou M, Pathak T, Robert A, Vandier C, Trebak M, Lecomte T, Raoul W.
Med Sci (Paris). 2021 Feb;37(2):124-126.


The anatomy of native CRAC channel(s).
Yoast RE, Emrich SM, Trebak M.
Curr Opin Physiol. 2020 Oct;17:89-95.

NCLX pumps up the heat.
Pathak T, Trebak M.
Cell Calcium. 2020 Dec;92:102280.

Dichotomous role of the human mitochondrial Na+/Ca2+/Li+ exchanger NCLX in colorectal cancer growth and metastasis.
Pathak T, Gueguinou M, Walter V, Delierneux C, Johnson MT, Zhang X, Xin P, Yoast RE, Emrich SM, Yochum GS, Sekler I, Koltun WA, Gill DL, Hempel N, Trebak M.
Elife. 2020 Sep 11;9:e59686.

Distinct pharmacological profiles of ORAI1, ORAI2, and ORAI3 channels.
Zhang X, Xin P, Yoast RE, Emrich SM, Johnson MT, Pathak T, Benson JC, Azimi I, Gill DL, Monteith GR, Trebak M.
Cell Calcium. 2020 Nov;91:102281

L-type Ca2+ channel blockers promote vascular remodeling through activation of STIM proteins.
Johnson MT, Gudlur A, Zhang X, Xin P, Emrich SM, Yoast RE, Courjaret R, Nwokonko RM, Li W, Hempel N, Machaca K, Gill DL, Hogan PG, Trebak M.
Proc Natl Acad Sci U S A. 2020 Jul 21;117(29):17369-17380.

The native ORAI channel trio underlies the diversity of Ca2+ signaling events.
Yoast RE, Emrich SM, Zhang X, Xin P, Johnson MT, Fike AJ, Walter V, Hempel N, Yule DI, Sneyd J, Gill DL, Trebak M.
Nat Commun. 2020 May 15;11(1):2444.

A new selective pharmacological enhancer of the Orai1 Ca2+ channel reveals roles for Orai1 in smooth and skeletal muscle functions.
Azimi I, Stevenson RJ, Zhang X, Meizoso-Huesca A, Xin P, Johnson M, Flanagan JU, Chalmers SB, Yoast RE, Kapure JS, Ross BP, Vetter I, Ashton MR, Launikonis BS, Denny WA, Trebak M, Monteith GR.
ACS Pharmacol Transl Sci. 2020 Feb 14;3(1):135-147.

Mitochondrial Calcium Regulation of Redox Signaling in Cancer.
Delierneux C, Kouba S, Shanmughapriya S, Potier-Cartereau M, Trebak M, Hempel N.
Cells. 2020 Feb 12;9(2):432.

Lipidic synthetic alkaloids as SK3 channel modulators. Synthesis and biological evaluation of 2-substituted tetrahydropyridine derivatives with potential anti-metastatic activity.
Kouba S, Braire J, Félix R, Chantôme A, Jaffrès PA, Lebreton J, Dubreuil D, Pipelier M, Zhang X, Trebak M, Vandier C, Mathé-Allainmat M, Potier-Cartereau M.
Eur J Med Chem. 2020 Jan 15;186:111854.